Discoveries in the realm of genetics and prostate cancer have been
brisk as of late, and among the latest findings are two inherited
genetic variants that can increase a man’s risk of developing prostate
cancer by threefold or fourfold. The findings appeared in the online
April 9 Proceedings of the National Academy of Sciences.
Among previous studies, scientists have discovered genetic markers linked to aggressive prostate cancer, and researchers at the University of Michigan Comprehensive Cancer Center even identified a prostate cancer gene called
SPINK1 that occurs in aggressive forms of prostate cancer. This latest
discovery adds to the growing knowledge about genetics and prostate
cancer risk.
More than 1,900 blood samples from men with prostate cancer and
healthy controls were examined for the study, and the scientists
discovered two different genetic variants or deletions in men who had
aggressive prostate cancer. One affects the functioning of a known gene,
and the other appears to regulate a cascade of genes. The second gene
variant was found in what is known as a “non-coding” area, which means
the gene does not make proteins, and this information is significant.
Why?
According to Dr. Mark A. Rubin, the Homer T. Hirst Professor of
Oncology in Pathology at Weill Cornell Medical College and one of the
researchers, “We used to think that only genes that made proteins were
responsible for disease, but this study shows us that there is inherited
information in the non-coding areas of the genome that appear to play a
strong role in development of cancer.”
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